Managing Pregnancy-Associated Thrombotic Microangiopathy

An international, multidisciplinary panel provides recommendations for diagnosis and treatment.

Sponsoring Organization: The International Working Group on Pregnancy-Related Thrombotic Microangiopathies

Background

Thrombotic microangiopathy (TMA) reflects a syndrome of endothelial injury associated with thrombocytopenia, mechanical hemolysis, and organ insult (kidney, brain, heart). Such findings can be observed in pregnancy, warranting urgent treatment. Now, an international, multidisciplinary panel has provided practical guidance for pregnancy TMA, including thrombotic thrombocytopenic purpura (TTP) and pregnancy-associated hemolytic uremic syndrome (p-HUS).

Key Recommendations

Pregnancy TMA should be suspected if the following are present: thrombocytopenia (<100×10⁹/L); acute kidney injury (less common in TTP); hemoglobin <10g/dL; lact…

Reviewing Author

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Brady L. Stein, MD, MHS

Disclosures

Leadership Positions in Professional SocietiesAmerican Society of Hematology (Senior Editor, ASH Self-Assessment Program; guideline development)

Managing Pregnancy-Associated Thrombotic Microangiopathy

Topics

Background

Key Recommendations

Reviewing Author