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Nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, and colchicine are oral options for treating patients with acute gout flares. Colchicine is a particularly attractive choice for patients with relative contraindications to NSAIDs and steroids. However, the official FDA prescribing directive for colchicine (1.2 mg at the first sign of a flare, followed by 0.6 mg 1 hour later) is inadequate, because it only covers the first day of treatment, and most patients require additional days of treatment. A new randomized trial fills this gap.
About 400 patients with acute gout flares received either naproxen (first dose, 750 mg; then 250 mg thrice daily for 1 week) or colchicine (0.5 mg thrice daily for 4 days); patients with glomerular filtrat…