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High-dose influenza vaccine contains four times more antigen than do standard preparations and is modestly more effective in preventing influenza and its complications among older adults (age, ≥65; NEJM JW Gen Med Sep 15 2017 and Lancet Respir Med 2017; 5:738). Might it also help other groups at high risk for flu complications?
In a partially industry-supported multicenter trial, researchers randomized 5200 U.S. and Canadian cardiac patients to receive either standard or high-dose vaccination for at least one flu season from 2016 to 2019. All participants had been hospitalized for acute myocardial infarction or heart failure at least once during the preceding 2 years and had at least one other medical red flag, such as diabetes, obesity, ren…