Baseline LDL Cholesterol Has a U-Shaped Association with All-Cause Mortality

All-cause mortality was lowest at an LDL cholesterol level of 140 mg/dL.

Elevated LDL cholesterol is a clear causal risk factor for cardiovascular disease (CVD). However, the association of LDL cholesterol level with all-cause mortality remains unclear, and the LDL cholesterol level associated with lowest mortality has not been defined. In this study, researchers collected baseline data on 108,000 randomly selected adults of Danish descent and examined associations between LDL cholesterol levels and mortality during median follow-up of 9 years.

After adjustment for other risk factors and comorbidities, the association between LDL cholesterol level and all-cause mortality was U-shaped, with both low and high levels of LDL cholesterol associated with excess mortality risk (adjusted hazard ratios, 1.25 and 1.15 for …

Reviewing Author

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Baseline LDL Cholesterol Has a U-Shaped Association with All-Cause Mortality

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Reviewing Author