The Alzheimer Disease Conversion-Related Pattern Score as Neurodegeneration Biomarker

To create a biological definition of Alzheimer disease (AD), the amyloid-tau-neurodegeneration (ATN) classification scheme has been developed. Researchers in this study assessed the validity of an AD conversion related pattern (ADCRP) score as a biomarker for ATN in 269 participants with mild cognitive impairment (MCI). ADCRP scores were derived from two types of positron emission tomography ([¹⁸F]FDG-PET of temporoparietal and precuneus/posterior cingulate activity, and [¹⁸F]AV-45 amyloid PET) through a computational modeling approach. Using cerebrospinal fluid (CSF) tau levels (T) and amyloid imaging (A), normal AD biomarkers were classified as A-T- (n=67), biologically defined AD as A+T+ (n=136), AD pathologic change as A+T- (n=22), and …