How Do Children Who Have MIS-C Compare with Those Who Have Severe Acute COVID-19?

U.S. case series identifies distinctions in clinical presentation and outcomes of multisystem inflammatory syndrome in children versus COVID-19.

Although children become infected with SARS-CoV-2 at lower rates and experience milder symptoms than adults (NEJM JW Pediatr Adolesc Med Dec 17 2020; [e-pub] and Pediatrics 2021; 147:e2020027268), a multisystem inflammatory syndrome in children (MIS-C) has been described that typically occurs after SARS-CoV-2 infection (NEJM JW Pediatr Adolesc Med Aug 2020 and N Engl J Med 2020; 383:347).

Children and adolescents younger than 21 were identified from the Overcoming COVID-19 network in a study of their clinical presentation and outcomes. Participants were hospitalized between March and October 2020 with either severe acute COVID-19 (577 patients) or meeting CDC criteria for MIS-C (539 patients). Key findings include the following:

Patients with…

Reviewing Author

Deborah Lehman, MD

Disclosures

Nothing to disclose

Deborah Lehman, MD

Disclosures

Nothing to disclose

How Do Children Who Have MIS-C Compare with Those Who Have Severe Acute COVID-19?

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Reviewing Author