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Concern about adverse effects — including kidney injury — appropriately deters use of nonsteroidal anti-inflammatory drugs (NSAIDs) in older patients. In this study, researchers used data from a longitudinal U.S. cohort study of 3000 older adults (mean age, 74) to examine associations between NSAID use and renal function. Documentation of NSAID use (over the counter or by prescription) was updated at annual visits. Although median follow-up was only 2 years, changes in glomerular filtration rate (GFR) were estimated through 10 years.
At baseline, mean GFR was 72 mL/minute/1.73 m2 and was not lower in NSAID users than in nonusers; additionally, NSAID users were not more likely to have albuminuria or abnormalities in urinary markers of renal t…