Brain Health in HIV Infection — Involvement of Non-HIV Risk Factors

Brain MRI changes and cognitive impairment in persons living with HIV are also linked to age, employment status, and various other comorbidities.

HIV's tendency to target the brain is well known, but identifying clinically meaningful correlates has been elusive. Now, two studies address this issue.

Mina and colleagues used MRI to identify white-matter hyperintensities (WMH; a common finding in persons living with HIV [PLWH]) in 203 persons with well-controlled HIV infection compared with 58 matched controls without HIV. They assessed the effect of HIV infection on WMH load while also determining other clinical variables associated with WMH. All participants underwent neuropsychological testing. The adjusted odds ratio for increased WMH in the PLWH group was 3.7 (adjusting for age and smoking). Within the PLWH group, higher WMH load was associated with older age, male sex, tobacco use,…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Brain Health in HIV Infection — Involvement of Non-HIV Risk Factors

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Reviewing Author