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In this study, researchers analyzed whether plasma neurofilament light chain (NfL) levels, a sensitive biomarker for neurodegeneration, could predict individuals with familial frontotemporal lobar degeneration (FTLD) who were at risk for clinical phenoconversion or disease progression from an original (n=277) and validation (n=297) cohort. Carriers included those with C9orf72, GRN, or MAPT mutations. Participants underwent neurologic assessments, caregiver/companion interviews, neuropsychological testing, neuroimaging, and clinical scales over 2 to 3 years. Clinical phenotypes were classified as asymptomatic, prodromal with mild behavioral impairment or mild cognitive impairment (MBI/MCI), and full phenotype (behavioral variant frontotempor…