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The etiology of cancer-associated thrombosis (CAT) is multifactorial, with influence from cancer stage, chemotherapy, postoperative state/immobility, prior thrombosis history, and presence of vascular access. The Khorana score incorporates cancer type, prechemotherapy blood cell counts (including use of erythropoietin stimulating agents), and body-mass index to create a risk score; however, greater precision in identifying at-risk patients would be welcomed. These investigators reviewed a large database, including more than 14,000 tumor samples (11,695 patients), to look for associations between tumor molecular profile and CAT.
Key findings include:
There were 693 episodes of CAT, with the highest event rate in patients with pancreatic cancer…