Family History of Colon Polyps Might Confer Excess Risk for Colorectal Cancer

The association was particularly strong for patients who developed colorectal cancer before age 50.

A person with a family history of colorectal cancer (CRC) has excess risk for developing CRC and might merit more-intensive CRC screening. Does a family history of colorectal polyps also confer excess risk for CRC? Existing evidence is inconclusive. Researchers used Swedish national registries to identify 68,000 adults with CRC and 333,000 matched controls (mean age, 63). Patients with hereditary CRC syndromes and histories of inflammatory bowel disease were excluded.

After adjusting for family history of CRC and other variables, having a first-degree relative with colorectal polyps was significantly more common among cases than among controls (8.4% vs. 5.7%; odds ratio, 1.40). ORs varied from 1.23 for hyperplastic polyps to 1.44 for tubulov…

Reviewing Author

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Bruce Soloway, MD

Disclosures

Editorial BoardsNew RoAR News (http://www.newroarnews.org)

Family History of Colon Polyps Might Confer Excess Risk for Colorectal Cancer

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Reviewing Author