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Fluoroquinolone antibiotics can be effective for treating serious infections in adolescents, such as complicated respiratory or urinary tract infections. In 2008, the FDA issued a boxed warning of potential tendon injury, yet scant data exist to quantify the risk among adolescents. These investigators used IBM Watson's MarketScan Commercial Claims and Encounters database (2000–2018) to evaluate tendon injury in adolescents aged 12 to 18 years. The primary exposure was an outpatient fill of a fluoroquinolone compared with a fill of a non-fluoroquinolone antibiotic. The primary outcome was tendon rupture within 90 days of the fill, defined by diagnosis and procedure codes for surgical tendon repair; the secondary outcome was tendinitis identi…