SARS-CoV-2 Seropositivity Is Not Associated with Low Vitamin D Levels

Risk for infection was not higher with 25-hydroxyvitamin D levels <20 ng/mL or <30 ng/mL.

Several studies — generally small and poorly controlled — have suggested that patients with low levels of vitamin D have excess risk for infection with SARS-CoV-2. This prospective cohort study involved 18,000 participants whose vitamin D levels were assessed both a few months prior to the COVID-19 pandemic and in the middle of the pandemic (August–November 2020). SARS-CoV-2 seropositivity was assessed through November 2020; clinical illness was not assessed.

Nine hundred participants (5%) became SARS-CoV-2–positive during the study. On univariate analysis, positivity was associated with low vitamin D levels and with various sociodemographic parameters. However, on multivariate analysis and with other methods of adjustment, seropositivity wa…

Reviewing Author

Thomas L. Schwenk, MD

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Thomas L. Schwenk, MD

Disclosures

Editorial BoardsUpToDate

SARS-CoV-2 Seropositivity Is Not Associated with Low Vitamin D Levels

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Reviewing Author