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In 2019, the European League Against Rheumatism and the American College of Rheumatology published the following classification criteria for systemic lupus erythematosus (SLE; Ann Rheum Dis 2019; 78:1151):
Positive antinuclear antibody (ANA) test with titer ≥1:80 is a required “entry criterion.”
If the ANA criterion is met, points are assigned from seven clinical categories and three immunologic test categories; a criterion is not counted if another cause is more likely than SLE.
A score ≥10 is considered to be consistent with SLE.
When these criteria were validated, sensitivity for SLE was 96%, and specificity was 93%.
Now, these researchers have published more detail on individual components of the criteria as applied to their original derivat…