For Solid Organ Transplant Recipients, Does the Second Dose of SARS-CoV-2 mRNA Vaccine Make a Difference?

Among 143 patients, only 29% had measurable spike protein antibodies — and four developed COVID-19.

Recipients of solid organ transplants (SOT) mount poor antibody responses to the first dose of SARS-CoV-2 mRNA vaccine (NEJM JW Infect Dis Jul 2021) — however, data are limited regarding responses after the full two-dose vaccination. In this retrospective observational study from a single medical center in France, 143 SOT recipients (58 liver, 59 kidney, and 26 heart) and 25 health care workers (HCW; control group) received two doses of the Pfizer-BioNTech vaccine 28 days apart. IgG antibody titers to the receptor binding domain of the SARS-CoV-2 spike protein were measured at baseline and 28 days after the first and second doses. Median time from transplant to vaccination was 45 months. Titers <50.0 arbitrary units/mL were considered negat…

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Neil M. Ampel, MD

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Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

For Solid Organ Transplant Recipients, Does the Second Dose of SARS-CoV-2 mRNA Vaccine Make a Difference?

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