Paraneoplastic Neurologic Syndromes Criteria

An international group of experts updated the 2004 criteria and developed a clinical scoring system called the Paraneoplastic (PNS)-Care Score.

Neurologic phenotypes associated with high risk for cancer (previously “classical PNS”) include encephalomyelitis, limbic encephalitis, rapidly progressive cerebellar syndrome, opsoclonus-myoclonus, sensory neuronopathy, gastrointestinal pseudo-obstruction, and Lambert-Eaton myasthenic syndrome. Intermediate-risk phenotypes have a rapidly progressive course and inflammatory cerebrospinal fluid (CSF) results or an abnormal brain or spine MRI. Intermediate-risk phenotypes are varied but can include encephalitis, brainstem encephalitis, peripheral nervous system presentations, and others. The authors li…