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Pancreatic cancer has a potential familial component in less than 10% of cases, usually suggested by a family history and subsequently confirmed by genetic testing. Given the increasing utilization of next-generation sequencing, data are emerging about the prevalence of heritable causes of pancreatic cancer. As heritable mutations are sometimes detected in the absence of a family history, genetic counseling and potential germline testing are recommended for all patients with newly diagnosed pancreatic cancer.
Investigators now report the results from a cohort study of pancreatic cancer registries in the U.S. and Canada. They evaluated 130 families and 2227 patients, with a focus on the prevalence and impact of pathogenic germline mutations i…