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An increasing number of men with low-risk prostate cancer are being managed with active surveillance in lieu of immediate, local curative intent therapy, although up to 55% of these men will undergo definitive intervention within 10 years. Given the disease biology and the age range of this population, it is no surprise that these patients have a 3-fold higher risk of cardiovascular- related death than prostate cancer–specific death.
In an effort to improve cardiovascular health and delay prostate cancer disease progression, investigators evaluated the effect of high-intensity interval training (HIIT) in low–intermediate risk patients deemed appropriate for active surveillance. In a phase 2 trial, patients were randomized to HIIT (supervised…