Thrombectomy for Acute Stroke Beyond 6 Hours: Enlarging the Database

With a larger patient group, the benefit of endovascular therapy is still visible, although some categories of patients were excluded.

Individual trials using strict enrollment criteria have shown that select patients with acute ischemic stroke can benefit from endovascular thrombectomy (EVT) when treated in the 6- to 24-hour time window. These trials were relatively small, and uncertainty exists about important patient subgroups. These authors conducted a manufacturer-funded meta-analysis of trials that enrolled patients for EVT beyond 6 hours after stroke onset. The primary outcome was functional independence at 90 days, judged by a modified Rankin Scale score of 0 to 2. Other endpoints of interest included mortality and symptomatic intracranial hemorrhage (sICH).

Data were included from six trials, among which DAWN and DEFUSE 3 were the largest. Among 505 patients (mean …

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Thrombectomy for Acute Stroke Beyond 6 Hours: Enlarging the Database

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Reviewing Author