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Sodium restriction and generous potassium intake are associated with lower blood pressure (BP), but the ultimate effect on cardiovascular (CV)-related morbidity is less clear. In 2021, several studies addressed this issue and refocused attention on these dietary interventions.
In a trial from China, 21,000 people with histories of stroke or inadequately controlled hypertension were randomized to replace regular salt with a salt substitute (75% sodium chloride, 25% potassium chloride) or to continue using regular salt; to further enhance sodium restriction, intervention participants were instructed to use the salt substitute more sparingly than they had used regular salt. At 5 years, rates of stroke, major adverse CV events, and mortality wer…