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Laparoscopic gastrectomy for gastric cancer is increasingly being adopted globally based on clinical trials demonstrating equivalent oncologic outcomes compared with open gastrectomy and potential reduction in operative morbidity, both in early-stage and more locally advanced gastric cancer.
Investigators in China now report 5-year survival results from the CLASS-01 trial in which 1056 patients with locally advanced gastric cancer were randomized to open or laparoscopic distal gastrectomy with D2 lymphadenectomy. The two arms were balanced in mean age (57–56), pathologic stage (II, 26%–27%; III, 42%–43%; N0, 41%–42%), and receipt of adjuvant chemotherapy (37%–42%).
Rates of 5-year overall survival were similar in the laparoscopic and open dis…