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Presenters at the 2021 meeting of the American Society of Hematology (ASH; December 11–14, 2021) reported the latest research in hematology. Here, NEJM Journal Watch Oncology and Hematology Associate Editor Dr. Brady L. Stein describes the key findings in benign hematology.
Prophylactic use of fitusiran, an investigational small interfering RNA (siRNA) therapeutic, is associated with a lower bleeding rate than on-demand bypassing agents (BPA) in people with hemophilia A or B with inhibitors, according to the industry-conducted, phase 3 ATLAS-INH study (abstract 4).
Nearly 60 males with hemophilia A or B with inhibitors who were taking on-demand BPA were randomized to r…