Predictors and Progression of Mild Cognitive Impairment in a Community-Based Cohort

ApoE4 positivity and higher medical burden increased risk for MCI; multidomain MCI, antidepressant use, depressive symptoms, and ApoE4 positivity were associated with clinical progression.

Mild cognitive impairment (MCI) is associated with subjective cognitive complaints, objective cognitive impairment, and absence of functional impairment — unlike dementia, with which functional impairment is present. To determine predictors and progression of MCI, investigators conducted a population-based cohort study involving 2903 participants from the Washington Heights–Inwood Columbia Aging Project (mean age, about 75 years; 70% female; 30% Black; 40% Hispanic) who were cognitively normal at baseline.

During a mean follow-up of 6.3 years, 752 participants (26%) developed incident MCI (25% multidomain; 75% single-domain), and 301 (10%) had dementia. Increased risk for incident MCI was associated with apolipoprotein E ℇ4 (apoE4) positivit…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Predictors and Progression of Mild Cognitive Impairment in a Community-Based Cohort

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Reviewing Author