Effect of Pulmonary Hypertension on Long-Term Outcome After Percutaneous Atrial Septal Defect Closure

Pulmonary hypertension is a risk factor for adverse cardiovascular outcomes after ASD closure.

Pulmonary hypertension (PH) is a risk factor for cardiovascular morbidity and mortality. In this retrospective study, investigators sought to determine the effects of preprocedure PH (defined as mean pulmonary pressure >20 mm Hg) on outcomes in 632 patients undergoing percutaneous atrial septal defect (ASD) closure. Results were as follows:

Patients with PH were older, had larger shunts, and had higher prevalences of tricuspid regurgitation and atrial fibrillation.
In-hospital outcomes were similar in patients with and without PH.
In adjusted analyses, at a median follow-up of 6.5 years, patients with PH had significantly higher incidence of adverse cardiac and cerebrovascular events than those without PH (hazard ratio, 2.45; 95 CI, 1.38–4.37)…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)