Cefazolin Inhibited Biofilm Formation by MRSA in Synovial Fluid

This activity of cefazolin might explain its success in preventing prosthetic joint infection despite in vitro resistance.

Preoperative cefazolin lowers risk for prosthetic joint infection (PJI) and has become standard of care. As bacterial biofilms represent a critical component in the pathophysiology of PJI, Pant and colleagues performed a study to evaluate the anti-biofilm and anti-planktonic activities of synovial fluid against three strains of Staphylococcus aureus (one methicillin-susceptible [MSSA] and two methicillin-resistant [MRSA]). Synovial fluid was obtained from 26 patients who received cefazolin prophylaxis as part of routine total knee arthroplasty.

Cefazolin minimum inhibitory concentrations (MICs) in bacteriologic media were 1.4 mg/L (MSSA) and 23 mg/L (MRSA). Interestingly, in synovial fluid, cefazolin MICs were 0.7 mg/L for the same strains. …

Reviewing Author

George Sakoulas, MD

Disclosures

Consultant/Advisory BoardParatek Pharmaceuticals; Nestle Corp.; AbbVie; Shionogi

Speaker’s BureauAllergan/AbbVie; Paratek Pharmaceuticals; Nestle Corp.

RoyaltiesUpToDate

Editorial BoardsAntimicrobial Agents and Chemotherapy; Open Forum Infectious Diseases