Does It Make a Difference Which COVID-19 Vaccine Is the Booster?

Both homologous and heterologous boosters appeared comparably safe and immunogenic.

“Which COVID-19 vaccine should I receive as a booster?” The NIH has now provided input regarding this common question with an interim report of the phase 1–2 MixNMatch Study, an open-label, nonrandomized, adaptive-design trial of 100-µg mRNA-1273 (Moderna), 5x10¹⁰ virus particles of Ad26.COV2 (Johnson & Johnson), or 30-µg BNT162b2 (Pfizer-BioNTech) to boost individuals who had completed an initial series with one of these three vaccines ≥12 weeks earlier and who had not experienced a COVID-19 episode.

Among 458 individuals enrolled between May and August 2021 (with similar numbers having received each of the 3 vaccines for their primary series), 154, 150, and 153 were boosted with the Moderna, Johnson & Johnson, and Pfizer-BioNTech vaccines,…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Does It Make a Difference Which COVID-19 Vaccine Is the Booster?

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Reviewing Author