Outcomes Improved with Intra-Arterial Alteplase After Successful Stroke Thrombectomy

But premature discontinuation of the phase 2b trial and small sample sizes mean that confirmatory studies are necessary.

Some patients are left with significant disability from large vessel occlusion stroke, even after a proximal occlusion is successfully recanalized. Although recent studies have examined whether bypassing intravenous thrombolysis before stroke thrombectomy makes sense or not, there has also been interest in whether adjunctive intra-arterial thrombolysis after successful stroke thrombectomy might more directly address remaining distal occlusions or microthrombi and improve outcomes.

This phase 2b trial evaluated the safety and preliminary efficacy of an adjunctive intra-arterial alteplase infusion (0.225 mg/kg; maximum of 22.5 mg) compared to placebo administered after successful stroke thrombectomy. Success was initially defined as reperfusio…

Reviewing Author

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

Anthony S. Kim, MD

Disclosures

Grant/Research SupportNIH/National Institute of Neurological Disorders and Stroke; NIH/National Center for Advancing Translational Sciences

Outcomes Improved with Intra-Arterial Alteplase After Successful Stroke Thrombectomy

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Reviewing Author