Endovascular Therapy for Acute Stroke with Significant Early Imaging Changes

Thrombectomy gives better outcomes (but at a greater risk for brain hemorrhage) than medical therapy in patients who would not have been considered eligible for the procedure under current guidelines.

Endovascular thrombectomy (EVT) for acute ischemic stroke is currently recommended for patients with only small/moderate amounts of early ischemic changes and large areas of hypoperfused tissue. It's thought that performing EVT in patients with large amounts of early ischemic change could be associated with a higher rate of brain hemorrhage.

This randomized trial evaluated EVT in acute stroke patients having ASPECTS scores of 3–5 of 10 (lower scores indicating larger amounts of ischemic change). This range was selected since current guidelines recommend scores of 6 or higher. Randomization was to either EVT (within 6 hours of stroke onset or within 24 hours if there were no infarct signs on FLAIR imaging) or medical care alone. The primary o…

Reviewing Author

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Seemant Chaturvedi, MD

Disclosures

Consultant/Advisory BoardBayer Pharmaceuticals; Novartis

Grant/Research SupportNational Institute of Neurological Disorders and Stroke

Editorial BoardsNeurology; Stroke

Endovascular Therapy for Acute Stroke with Significant Early Imaging Changes

Topics

Reviewing Author