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Observational studies have yielded inconsistent associations for the effects of statin therapy on COVID-19 outcomes. Statins' effects on inflammation, endothelial function, and coagulation, and their upregulation of the ACE2 receptor, are theoretical reasons that they could be beneficial. To assess the effect of discontinuing statin therapy, researchers analyzed records of nearly 150,000 adult patients with COVID-19 who were admitted to facilities within a large U.S. healthcare system. Only patients who were receiving atorvastatin (93% of cohort) were considered in the analysis. Patients were divided into three statin-therapy categories: (1) continuous (home plus in hospital); (2) discontinued (home, but not in hospital); (3) no statins.
In …