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The overuse of acute pain medication is common in patients with chronic migraine (CM) and is associated with developing more frequent headaches. To determine the optimum treatment strategy for addressing chronic migraine with medication overuse (CMMO), researchers conducted an open-label clinical trial. They randomized 720 adult participants 1:1 to migraine preventive medication and (a) switching from the overused medication to an alternative used no more than 2 days/week, or (b) continuation of the overused medication with no maximum limit. The primary outcome was moderate to severe headache day frequency at weeks 9 through 12 and during weeks 1 and 2 after randomization.
Migraine preventive medication without switching of the overused medi…