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The recognition that antibiotic therapy markedly alters the gut microbiome, as demonstrated by Clostridioides difficile disease, raises the question of how markedly antibiotic therapy may alter the microbiome at other body sites. Researchers have recently assessed the effect of antibiotic therapy for skin and soft tissue infections (SSTIs) on the skin microbiome. They analyzed samples from 9 body sites in 10 outpatients with acute suppurative SSTIs before and after antibiotic therapy compared with 10 healthy controls. Sites included the nares, oropharynx, infection site, and 6 other skin sites.
Microbiome samples predominantly revealed Firmicutes, Actinobacteria, and Bacteroidetes species. At almost all noninfected body sites, samples did no…