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Some adverse-event reports and trial data suggest immunization with an mRNA COVID-19 vaccine is associated with developing appendicitis. In this study, Danish researchers used national registry data to identify all recipients of either the Pfizer-BioNTech or Moderna vaccines and all adolescents and adults (age, ≥12) with PCR-confirmed SARS-CoV-2 infections between December 2020 and November 2021; the comparison group comprised all unvaccinated people who were tested for SARS-CoV-2 infections.
Among ≈4 million people who were immunized with mRNA vaccines, incidence of acute appendicitis within 21 days of either a first or second dose was about 8 episodes per 100,000 vaccinated people. Compared with the unvaccinated reference group, no excess …