Fine-Grained Analysis of SARS-CoV-2 Viral Dynamics

Viral kinetics and infectivity differed substantially across individuals and for nasal versus saliva samples.

Given that many important questions about the natural history of SARS-CoV-2 infection remain unanswered, researchers utilized a university-based COVID-19 screening program (fall 2020 and spring 2021) in a detailed analysis of early SARS-CoV-2 infections. Participants who were within 24 hours of a positive SARS-CoV-2 PCR result or within 5 days of exposure to a PCR-positive individual underwent daily nasal and saliva sample analyses for 14 days. Among 60 subjects, none had had prior COVID-19 or vaccination against SARS-CoV-2, and all infections were mild or asymptomatic.

Substantial heterogeneity in viral dynamics was observed. Lower PCR cycle number (CN) was generally associated with both overall and more-rapid viral culture positivity (alth…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Fine-Grained Analysis of SARS-CoV-2 Viral Dynamics

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Reviewing Author