Axon loss and microglia occur on the surface of the thalamus exposed to CSF.
In patients with multiple sclerosis (MS), leptomeningeal inflammatory infiltrates have been associated with cortical subpial lesions (NEJM JW Neurol Aug 2020 and Ann Neurol 2020; 88:562). The thalamus has also been noted to contain ependymal lesions in MS (Ann Neurol 2020; 88:81). In this study, investigators evaluated postmortem tissue from 41 patients with secondary-progressive MS, 12 with non-MS neurologic diseases, and 5 nonneurologic disease controls, to determine whether cerebrospinal fluid (CSF) inflammatory markers were also associated with MS-specific changes in the dorsomedial thalamus.
Demyelination was observed in 90% of the MS samples. An increased density of MHC-II+ microglia were found close to the CSF/ependymal boundary in th…
Reviewing Author
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)
DisclosuresConsultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics
Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense
Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)