Are Proton-Pump Inhibitors Associated with Development of Diabetes?

This association was found in another observational study; a potential mechanism has been proposed.

In a recent observational study, prolonged use of proton-pump inhibitors (PPIs) was associated with development of diabetes (NEJM JW Gastroenterol Nov 2020 and Gut 2021; 70:1070). Now, a case-control study drawn from a National Health Service database in Italy addresses the same issue.

Fifty thousand adults (age, ≥40) who developed diabetes during a 5-year interval were compared with 50,000 people without diabetes, matched on age, sex, and an elaborate clinical status score. In analyses adjusted for numerous potentially confounding variables, researchers detected a significant relation between exposure to a PPI and a new diagnosis of diabetes. With PPI exposures of 2 to 6 months, 6 to 24 months, and >24 months, odds ratios for developing dia…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Are Proton-Pump Inhibitors Associated with Development of Diabetes?

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Reviewing Author