Loading...
Hypertension remains a leading cause of morbidity and mortality throughout the world. Several studies, including the Salt Substitute and Stroke Study (SSaSS; NEJM JW Gen Med Oct 1 2021 and N Engl J Med 2021; 385:1067) indicate benefits of salt substitutes for blood pressure reduction and clinical outcomes. To assess whether these benefits are consistent across all available trials, researchers conducted a meta-analysis of 21 trials of salt substitutes that included 31,949 participants.
The SSaSS study alone contributed 20,995 participants and most of the clinical outcomes. Nineteen trials reported blood pressure effects and five reported clinical outcomes. The interventions varied, with the proportion of potassium chloride in the salt substi…