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Vasovagal syncope is extremely common and lacks effective therapies. Early reports of ablation of the ganglionated plexus in the atrium appeared to show benefit but were from observational studies. Now, researchers report findings of a small, randomized trial of cardioneuroablation for reducing syncope recurrence.
Among 48 patients with vasovagal syncope enrolled, 24 underwent radiofrequency ablation of ganglionic plexi in the right and left atrium. (The anatomical areas of the ganglionic plexi were confirmed by mapping sites of fractionated potentials.) The other 24 patients (controls) continued receiving optimal nonpharmacological therapy.
During 2-year follow-up, the primary endpoint of recurrent syncope occurred in 2 patients (8%) in the …