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The genetic disorder Marfan syndrome is associated with progressive aortic dilation and the attendant risk for aortic dissection. To assess how angiotensin-receptor blockers (ARBs) and beta-blockers affect progression of aortic-root enlargement, as measured by aortic-root Z scores, investigators conducted an individual-level meta-analysis of randomized trials that had compared ARB with control treatment (typically placebo) or ARB with beta-blocker therapy in patients with Marfan syndrome and no previous aortic surgery. Seven trials were ultimately eligible for analysis: four ARB versus control (676 patients; mean age, 29 years), three ARB versus beta-blocker (766 patients; mean age, 14 years). Median follow-up was 3 years in both sets of tr…