Asymptomatic Lesions in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Whereas subclinical MRI lesions are often encountered in multiple sclerosis (MS) patients, their frequency in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) or aquaporin-4 positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) has been under debate.

Investigators have now conducted a retrospective study to identify the frequency of new or enlarging T2-hyperintense or enhancing lesions outside of clinical attacks in 105 MOGAD patients (median age, 31 years; 60% female) and to compare the relative frequency of such lesions in MOGAD patients versus MS or AQP4+NMOSD patients. The researchers evaluated 373 paired baseline and follow-up MRI scans of the MOGAD patients and compared results among subgroup…