Perivascular Spaces and Dementia Risk

The burden of perivascular spaces on brain MRI affected dementia risk in community-dwelling adults.

Perivascular spaces (PVS) may be a brain MRI proxy measure for pathophysiologic changes such as cerebral small vessel disease (CSVD) and glymphatic dysfunction. Researchers analyzed whether PVS burden was associated with incident all-cause dementia, Alzheimer dementia (AD), and vascular dementia (VaD) in 1449 community-dwelling participants aged ≥50 years (mean age at MRI, 69 years; 46% male) from the Framingham Heart Study. PVS were defined as having a signal intensity similar to the cerebrospinal fluid (CSF), adherence to the course of penetrating vessels, a linear or round appearance, and a diameter smaller than 3 mm. The investigators used consensus criteria to determine PVS burden in the basal ganglia (BG) and centrum semiovale (CSO) a…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Perivascular Spaces and Dementia Risk

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Reviewing Author