Loading...
Clinical subtypes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are characterized by immunoglobulin heavy chain variable gene (IGHV) mutation status, fluorescent in situ hybridization (FISH) and standard cytogenetics, and TP53 gene mutation status. Investigators now report a comprehensive genomic, transcriptomic, and epigenetic analysis of CLL/SLL and monoclonal B lymphocytosis, a prodromal phase of CLL. The molecular data were correlated with clinical outcomes to identify new prognostic models and potentially targetable anomalies.
The 1095 CLL/SLL samples in the multinational study were from patients under observation and without prior therapy (n=680), patients post treatment (n=52), and clinical trial enrollees who w…