Is It Ever Too Early to Use Fecal Microbiota Transplantation for C. difficile Disease?

Due to the beneficial effects of FMT, a placebo-controlled trial assessing this treatment for first or second episodes of C. difficile infection was stopped at the interim analysis.

Multiple studies have shown that fecal microbiota transplantation (FMT) is highly efficacious against recurrent Clostridioides difficile infection (CDI), but whether FMT would be of similar benefit for early CDI has been less clear. Investigators at a Danish academic medical center undertook a randomized trial of two doses of placebo versus FMT (prepared from rigorously screened donors and given in oral capsules) administered within 7 days of completing the initial treatment (≥10 days of oral vancomycin in all participants). The primary outcome was resolution of CDI 8 weeks after the second study dose.

After 42 patients had been enrolled, the trial was stopped when an interim analysis found that 19 of 21 FMT recipients (90%) had CDI resoluti…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Is It Ever Too Early to Use Fecal Microbiota Transplantation for C. difficile Disease?

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Reviewing Author