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Although epilepsy and Parkinson disease (PD) have a known association, the contributory role of antileptic agents has not been examined previously. In this nested case-control study, researchers studied the risk for PD with exposure to carbamazepine, lamotrigine, levetiracetam, and sodium valproate in 500,000 longitudinally enrolled participants in the UK Biobank, 45% of whom had linked data on primary care prescriptions. The final study cohort contained 1433 individuals with PD diagnosis based on Hospital Episode Statistics (HES) code (mean age, 71 years; 61% male; 98% white) and 8598 controls matched for age, sex, race and ethnicity, and socioeconomic status.
Individuals receiving antiepileptic prescriptions were at increased odds of devel…