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For the average-risk person with negative findings at colorectal cancer screening colonoscopy, guidelines recommend follow-up screening colonoscopy in 10 years (NEJM JW Gen Med Jun 15 2021 and JAMA 2021; 325:1978). However, this recommendation is based on limited evidence. In this cross-sectional study, researchers used a large German screening colonoscopy registry and determined the prevalence of advanced neoplasm (i.e., advanced adenoma or cancer) ≥10 years after a negative screening colonoscopy. Advanced adenoma was defined as >1 cm in size, villous components, or high-grade dysplasia.
From a total of 1.2 million older people (age, ≥65) who underwent screening colonoscopy, researchers identified 120,000 who underwent repeat screening colo…