Adding Chlorfenapyr to Pyrethroid-Treated Bed Nets Improved Protection Against Malaria-Transmitting Mosquitoes

In an area of Benin with pyrethroid-resistant mosquitoes, insecticidal bed nets containing the chlorfenapyr-pyrethroid combination were better at preventing malaria.

Mosquitoes resistant to pyrethroids may be undermining the gains achieved with long-lasting insecticidal bed nets (LLINs), a cornerstone of malaria control strategies in Africa. Investigators in Benin conducted a cluster-randomized trial in an area with high pyrethroid resistance to evaluate the efficacy of LLINs treated with two insecticides (pyriproxyfen-pyrethroid or chlorfenapyr-pyrethroid) compared with pyrethroid-treated LLINs. One LLIN was distributed for every 2 household members; thus, >115,000 bed nets were distributed to 54,030 households. Bed net usage varied from 77% at 9 months after distribution to 61% at 24 months.

During 2 years' follow-up of children aged 6 months to 10 years, malaria incidence was 46% lower among those liv…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Adding Chlorfenapyr to Pyrethroid-Treated Bed Nets Improved Protection Against Malaria-Transmitting Mosquitoes

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Reviewing Author