Clarification on Which Patients Benefit from Cardiac Resynchronization

In a meta-analysis, only those with QRS duration ≥150 ms and either left bundle branch block or intraventricular conduction delay benefitted from CRT.

Cardiac resynchronization therapy (CRT) has the potential to improve quality of life, decrease heart failure hospitalizations, and improve longevity in patients with dilated cardiomyopathies and conduction system disease. However, results of randomized controlled trials (RCTs) are conflicting as to who benefits from CRT, largely due to small numbers of patients with right bundle branch block. To provide further data to inform this clinical decision, researchers conducted a patient-level meta-analysis from seven RCTs.

Among 6264 patients (25% women), 61% received CRT. The majority (73%) had left bundle branch block (LBBB), 16% had nonspecific intraventricular conduction delay (IVCD), and 11% had right bundle branch block (RBBB). CRT was assoc…

Reviewing Author

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

Mark S. Link, MD

Disclosures

Editorial BoardsCirculation; UpToDate

Clarification on Which Patients Benefit from Cardiac Resynchronization

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Reviewing Author