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Historically, guidance for percutaneous coronary intervention (PCI) has relied on two-dimensional images from coronary angiography; however, three-dimensional imaging using either intravascular ultrasound (IVUS) or optical coherence tomography (OCT) provides substantial additional information (e.g., luminal dimensions, lesion morphology). Although several randomized trials have demonstrated improved PCI outcomes with IVUS guidance, it is unclear whether these findings extend to other forms of imaging, and current U.S. and European guidelines recommend use of intravascular imaging in selected patients only.
To further inform this debate, investigators conducted the industry-funded RENOVATE-COMPLEX-PCI trial (NCT03381872), randomizing 1639 pat…