Potential Utility of α-Synuclein RT-QuIC Assay in Isolated RBD

The RT-QuIC assay in the skin and cerebrospinal fluid shows high specificity for alpha-synuclein activity in isolated REM sleep behavior disorder.

α-synuclein (α-syn) seeding activity in cerebrospinal fluid (CSF), identified via real-time quaking-induced conversion (RT-QuIC), is a potential biomarker for Parkinson disease (PD), mild cognitive impairment, and dementia with Lewy bodies. Isolated REM sleep behavior disorder (iRBD) can occur years before onset of cognitive and motor symptoms in Lewy body disease. In this cross-sectional study, researchers tested RT-QuIC assays in skin and CSF in 91 participants with polysomnography-confirmed iRBD (mean age, 70 years; 77% male) and 41 controls (59% male). Each participant provided 6 skin biopsies from the cervical region and distal legs and underwent assessments of cognition, motor function, smell, orthostatic hypotension (OH), constipatio…

Reviewing Author

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Jennifer Rose V. Molano, MD

Disclosures

Grant/Research SupportNational Center for Advancing Translational Science – Cincinnati Center for Clinical and Translational Science and Training

Editorial BoardsBrain & Life

Potential Utility of α-Synuclein RT-QuIC Assay in Isolated RBD

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Reviewing Author