Patients Hospitalized for Severe Infection Have Subsequent Excess Risk for Cardiovascular Events

Short-term chances were especially pronounced among those with preexisting cardiovascular disease risk factors.

Although various infections are known to raise risk for myocardial infarction and stroke, details on infection type, duration of elevated risk for cardiovascular events (CVE), and contribution of infections to the general burden of observed CVE remain unquantified. In a prospective multicohort analysis that included 331,683 patients in the U.K. Biobank and 271,329 study participants from Finland without known CVD at baseline, Sipilä and colleagues assessed CV risk and postinfection incidence of major CVE (myocardial infarction, stroke, or cardiac death). Short- and long-term risk for CVE were both evaluated.

Among U.K. Biobank participants (mean follow-up, 11.6 years), those hospitalized for infection had excess risk for CVE that was most pr…

Reviewing Author

George Sakoulas, MD

Disclosures

Consultant/Advisory BoardParatek Pharmaceuticals; Nestle Corp.; AbbVie; Shionogi

Speaker’s BureauAllergan/AbbVie; Paratek Pharmaceuticals; Nestle Corp.

RoyaltiesUpToDate

Editorial BoardsAntimicrobial Agents and Chemotherapy; Open Forum Infectious Diseases