Loading...
Many different antihypertensives are available on the market, and it is not always clear which agent might offer the best blood pressure (BP) lowering for a given patient. To determine whether individuals responded better to one antihypertensive monotherapy versus another, investigators performed a randomized, double-blind, repeated crossover trial in low-risk patients with hypertension recruited from an outpatient research clinic in Sweden (NCT02774460).
Two hundred eighty patients (mean age, 64; 54% men; mean office BP, 154/89 mm Hg) were randomized to sequential treatment with four different classes of single, once-daily, blood pressure–lowering medications, two of which were repeated to see if BP response changed. The agents were lisinop…